As mentioned above, "Anyone But You" stars Glen Powell and Sydney Sweeney as the two romantic leads.

Powell, who recently gained widespread attention for his role in "Top Gun: Maverick," is no stranger to the romantic comedy. In 2018, he starred opposite Zoey Deutch in the Netflix rom-com "Set it Up." Other notable projects of his include the 2016 historical drama "Hidden Figures" and the 2015 satirical slasher TV series "Scream Queens." Besides "Anyone But You," Powell has a few more upcoming projects in the works, including the remake of "Twister" and Richard Linklater's "Hit Man." 

Sweeney, of course, is best known for her roles in "Euphoria" and "The White Lotus" Season 1, both of which earned her Emmy nominations. Before "Euphoria," Sweeney gained attention for her roles in "The Handmaid's Tale" and "Sharp Objects," both in 2018. Other recent projects include two 2021 films, erotic thriller "The Voyeurs" and vampire thriller "Night Teeth." Alongside "Anyone But You," Sweeney's upcoming projects include her introduction to the world of superheroes with "Madame Web," in which she will play Julia Carpenter.

Alongside Powell and Sweeney, "Anyone But You" also features Dermot Mulroney, who is no stranger to rom-coms, having starred opposite Julia Roberts in "My Best Friend's Wedding," as well as opposite Debra Messing in "The Wedding Date." Michelle Hurd ("Star Trek: Picard"), Alexandra Shipp ("X-Men: Apocalypse"), Darren Barnet ("Never Have I Ever"), Rachel Griffiths ("Hacksaw Ridge"), Hadley Robinson ("Winning Time: The Rise of the Lakers Dynasty"), GaTa ("Dave"), and Bryan Brown ("The Thorn Birds") also co-star.