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| Gene | Type | Skill | Kinship Cost | Effect | Can Critical | Upgrade Effects | Monsters |
| Whip Gene (S) | Technical | Tail Spin | 16 | Light non-elemental damage to all | Yes | Power++ | Pukei-Pukei |
| Full Swing Gene (L) | Power | Ruinous Tackle | 19 | Heavy non-elemental damage to one | Yes | Power++ | Nergigante |
| Full Swing Gene (XL) | Speed | Hellish Heavyweight | 38 | Heavy non-elemental damage to all | Yes | Power++ | Bloodbath Diablos |
| Piercing Claws Gene (S) | Technical | Beak Drill | 8 | Light non-elemental damage to one | Yes | Power++ | Yian Kut-Ku Blue Yian Kut-Ku |
| Piercing Claws Gene (XL) | Speed | Venom Sweep | 41 | Heavy non-elemental damage to all 30% chance Poison (3 turns) | Yes | Power++ Rate++ 50% at max | Pink Rathian |
| Tackle Gene (S) | Technical | Unstoppable | 16 | Light non-elemental damage to all | Yes | Power++ | Yian Kut-Ku |
| Tackle Gene (L) | Power | Great Smasher | 20 | Medium non-elemental damage to all | Yes | Power++ | Brachydios |
| Smash Gene (XL) | Power | Venom Strike | 21 | Heavy non-elemental damage to one 30% chance of Poison (3 turns) | Yes | Power++ Rate++ 50% at max | Rathalos |
| Chomp Gene (M) | Power | Wild Fang | 10 | Medium non-elemental damage to one | Yes | Power++ | Lagiacrus Fulgur Anjanath |
| Rock Gene (S) | Power | Rock Stampede | 8 | Light non-elemental damage to one | Yes | Power++ | Kulu-Ya-Ku |
| Dash Gene (S) | Power | Ground Tremor | 16 | Light non-elemental damage to all | No | Power++ | Aptonoth |
| Dash Gene (L) | Speed | Vacuum Blast | 30 | Medium non-elemental damage to all 60% chance of Bleeding (2 turns) | No | Power++ Rate++ 80% at max | Silverwind Nargacuga |
| Dash Gene (XL) | Power | Ground Crusher | 19 | Heavy non-elemental damage to one | Yes | Power++ | Grimclaw Tigrex |
| Tumbling Gene (S) | Technical | Air Blast | 14 | Light non-elemental damage to one 10% chance of Stun | No | Power++ Rate++ 30% at max | Paolumu |
| Tumbling Gene (M) | Power | Tail Stun | 16 | Medium non-elemental damage to one 10% chance of Stun | Yes | Power++ Rate++ 30% at max | Gypceros |
| Tumbling Gene (L) | Power | Takedown | 16 | Medium non-elemental damage to one 10% chance of Knockdown | Yes | Power++ Rate++ 30% at max | Monoblos |
| Breaking Gene (S) | Technical | Wild Breaker | 9 | Light non-elemental damage to one 10% chance of Lowered Defense x0.85 (3 turns) | Yes | Power++ Rate++ 30% at max | Arzuros Great Jaggi Barroth |
| Breaking Gene (M) | Power | Breakthrough Strike | 12 | Medium non-elemental damage to one 20% chance of Lowered Defense x0.85 (3 turns) | Yes | Power++ Rate++ 40% at max | Jade Barroth Brute Tigrex White Monoblos |
| Breaking Gene (XL) | Speed | Hellbreaker | 22 | Heavy non-elemental damage to one 20% chance of greatly Lowered Defense x0.7 (3 turns) | Yes | Power++ Rate++ 40% at max | Bloodbath Diablos |
| Head Start Gene (S) | – | Rapid Bite | 14 | Very light non-elemental damage to one Very high chance to strike first | Yes | Power++ | Velocidrome |
| P Head Start Gene (L) | Power | Sonic Strike P | 16 | Light non-elemental damage to one Very high chance to strike first | Yes | Power++ | Rajang |
| S Head Start Gene (L) | Speed | Sonic Strike S | 16 | Light non-elemental damage to one Very high chance to strike first | Yes | Power++ | Monoblos |
| Onslaught Gene (S) | Speed | Killer Strike | 18 | Light non-elemental damage to one +20% chance to crit | Yes | Power++ | Velocidrome |
| Onslaught Gene (M) | Technical | Killer Crush | 18 | Light non-elemental damage to one +20% chance to crit | Yes | Power++ | Apceros Paolumu |
| All-Out Gene (S) | Speed | Maximum Attack | 10 | Medium non-elemental damage to one Recoil damage | Yes | Power++ | Bulldrome Blue Yian Kut-Ku |
| All-Out Gene (M) | Power | Maximum Claw Slash | 10 | Heavy non-elemental damage to one Knocks down user | Yes | Power++ | Arzuros |
| All-Out Gene (XL) | Power | Maximum Horn Jab | 38 | Massive non-elemental damage to all Recoil damage and knocks down user | Yes | Power++ | Diablos Black Diablos |
| Last Stand Gene (S) | Technical | Vengeful Attack | 8 | Light non-elemental damage to one Attack boosted at low HP | Yes | Power++ | Paolumu Nerscylla |
| Last Stand Gene (M) | Power | Vengeful Tackle | 10 | Medium non-elemental damage to one Attack boosted at low HP | Yes | Power++ | Diablos |
| Rampage Gene (S) | Power | Lethal Tackle | 13 | Light non-elemental damage to one 30% accuracy, guaranteed crit | Yes | Accuracy++ | Bulldrome |
| Rampage Gene (M) | Technical | Heavy Strike | 20 | Medium non-elemental damage to one 30% accuracy, guaranteed crit | Yes | Accuracy++ | Ash Kecha Wacha |
| Rampage Gene (L) | Speed | Heavy Spear | 29 | Heavy non-elemental damage to one 30% accuracy, guaranteed crit | Yes | Accuracy++ | Tigrex |
| Rampage Gene (XL) | Power | Heavy Rampage | 56 | Massive non-elemental damage to all 30% accuracy, guaranteed crit | Yes | Accuracy++ | Grimclaw Tigrex |
| Sleep Gene (S) | Speed | Drowsy Fang | 10 | Light non-elemental damage to one 15% chance of Sleep (1 turn) | Yes | Power++ Rate++ 35% at max | Great Baggi |
| Sleep Gene (M) | Technical | Sleep Needle | 11 | Light non-elemental damage to one 30% chance of Sleep (1 turn) | Yes | Power++ Rate++ 50% at max | Nerscylla |
| Sleep Gene (L) | Technical | Sleep Gas | 26 | Medium non-elemental damage to all 30% chance of Sleep (same turn only) | No | Power++ Rate++ 50% at max | Gravios Ruby Basarios |
| Poison Gene (S) | Technical | Poison Tail | 9 | Light non-elemental damage to one 15% chance of Poison (3 turns) | Yes | Power++ Rate++ 35% at max | Yian Garuga |
| Poison Gene (M) | Speed | Poison Spike | 12 | Medium non-elemental damage to one 30% chance of Poison (3 turns) | Yes | Power++ Rate++ 50% at max | Rathian |
| Poison Breath Gene (S) | Technical | Venom Shot | 10 | Light non-elemental damage to one 30% chance of Poison (3 turns) | No | Power++ Rate++ 50% at max | Pukei-Pukei |
| Poison Breath Gene (M) | Technical | Venom Blaster | 21 | Light non-elemental damage to all 60% chance of Poison (3 turns) | No | Power++ Rate++ 80% at max | Pukei-Pukei |
| Venom Gene (S) | Power | Venom | 9 | Light non-elemental damage to one 15% chance of Poison (3 turns) | No | Power++ Rate++ 35% at max | Gypceros Iodrome |
| Paralyze Gene (S) | Speed | Paralysis Fang | 10 | Light non-elemental damage to one 10% chance of Paralysis (3 turns) | Yes | Power++ Rate++ 30% at max | Gendrome |
| Paralyze Gene (M) | Technical | Paralysis Slash | 11 | Light non-elemental damage to one 20% chance of Paralysis (3 turns) | Yes | Power++ Rate++ 40% at max | Cephadrome |
| Arachno Venom Gene (M) | Technical | Parapoison Chaser | 10 | Medium non-elemental damage to one More damage to Poisoned or Paralyzed target | Yes | Power++ | Iodrome Gendrome Shrouded Nerscylla |
| Arachno Venom Gene (L) | Technical | Arachnophobia | 13 | Medium non-elemental damage to one 15% chance of Poison/Paralysis (3 turns) | Yes | Power++ Rate++ 35% at max | Shrouded Nerscylla |
| Arachno Venom Gene (XL) | Technical | Toxic Needle | 23 | Light non-elemental damage to one 60% chance of Poison 5% chance of OHKO | No | KO Rate++ 80% Poison 25% OHKO | Shrouded Nerscylla |
| Savage Roar Gene (S) | Power | Roar | 19 | Light non-elemental damage to all 15% chance of knockdown | No | Power++ | Khezu Black Diablos |
| Savage Roar Gene (XL) | Power | Savage Roar | 25 | Medium non-elemental damage to all 60% chance of knockdown | No | Power++ Rate++ 80% at max | Brute Tigrex Bloodbath Diablos |
| Foul Gas Gene (S) | Technical | Foul Gas | 10 | Light non-elemental damage to one 30% chance of Stench (3 turns) | No | Power++ Rate++ 50% at max | Congalala |
| Foul Gas Gene (M) | Technical | Smelly Breath | 16 | Light non-elemental damage to one 30% chance of Burn, Poison, Paralysis | No | Power++ Rate++ 50% at max | Congalala Emerald Congalala |
| Foul Gas Gene (L) | Technical | Blighting Fumes | 13 | Medium non-elemental damage to one 30% chance of Stench, Blastblight | No | Power++ Rate++ 50% at max | Emerald Congalala |
| Noxious Poison Gene (S) | Power | Noxious Venom | 9 | Light non-elemental damage to one 15% chance of Noxious Poison (3 turns) | No | Power++ Rate++ 35% at max | Purple Gypceros |
| Noxious Poison Gene (L) | Technical | Toxic Sweep | 42 | Heavy non-elemental damage to all 30% chance of Noxious Poison (3 turns) | Yes | Power++ Rate++ 50% at max | Dreadqueen Rathian |
| Noxious Poison Gene (XL) | Speed | Venom Queen | 31 | Heavy non-elemental damage to one 60% chance of Severe Poison (3 turns) | Yes | Power++ Rate++ 80% at max | Dreadqueen Rathian |
| Savage Strike Gene (S) | – | Rock Shooter | 9 | Medium non-elemental damage to a random target | No | Power++ | Tigrex Brute Tigrex |
| Savage Strike Gene (M) | – | Rock Slugger | 18 | Heavy non-elemental damage to a random target | No | Power++ | Grimclaw Tigrex |
| Spikeshot Gene (S) | – | Spike Bomb | 16 | Light non-elemental damage to all | No | Power++ | Nargacuga Green Nargacuga |
| Spikeshot Gene (M) | Speed | Stun Spike Bomb | 38 | Medium non-elemental damage to all 15% chance of Stun | No | Power++ Rate++ 35% at max | Green Nargacuga |
| Spikeshot Gene (L) | Technical | Shredding Scales | 25 | Medium non-elemental damage to all 30% chance of Bleeding (2 turns) | No | Power++ Rate++ 50% at max | Seregios |
| Spikeshot Gene (XL) | Speed | Guided Spike Bomb | 19 | Heavy non-elemental damage to one Guaranteed hit | No | Power++ | Silverwind Nargacuga |
| Toss Gene (S) | Technical | Rock Launcher | 8 | Light non-elemental damage to one | No | Power++ | Kulu-Ya-Ku |
| Soothing Gene (S) | – | Soothing Voice | 36 | Heals an ally | – | Restores more HP | Aptonoth |
| Healing Gene (M) | – | Honey Power | 26 | Restores small HP at the start of the turn (3 turns) | – | Up to 5 turns | Arzuros |
| Healing Gene (L) | – | Mushroom Power | 40 | Fully heals the user | – | Heal over time (2 turns) | Congalala |
| Healing Gene (XL) | – | Heartfelt Gift | 96 | Restores 1 heart | – | Also restores HP | Aptonoth Apceros Popo |
| Recovery Gene (S) | – | Healing Hum | 16 | Cures an ally of abnormal statuses | – | Also restores HP | Aptonoth |
| Recovery Gene (M) | – | Healing Roar | 20 | Cures all allies of abnormal statuses | – | Also restores HP | Popo |
| Toughen Gene (L) | – | Rock Shield | 17 | Moderately increases user’s defense x1.3 (3 turns) | – | Up to 5 turns | Basarios Ruby Basarios Black Gravios |
| Guard Gene (S) | – | Stone Shield | 16 | Slightly increases user’s defense x1.15 (3 turns) | – | Up to 5 turns | Kulu-Ya-Ku |
| Guard Gene (M) | – | Perfect Guard | 11 | Huge damage reduction (1 turn) | – | Effect+++ 85% at max | Emerald Congalala |
| Lock-On Gene (L) | – | Lock-On | 6 | Raises user’s accuracy next turn | – | Accuracy+++ | Tigrex White Monoblos |
| Critical Gene (S) | – | Sharpen Blades | 15 | Slightly increases user’s attack x1.15 Increases crit rate +15% (3 turns) | – | Up to 5 turns | Nargacuga Palamute |
| Critical Gene (M) | – | Sneak | 21 | Slightly increases user’s evasion +15% Increases crit rate +15% (3 turns) | – | Up to 5 turns | Green Nargacuga |
| Evasion Gene (L) | – | Critical Eye | 21 | Evades attacks until the end of the turn (1 attack) | – | Up to 3 attacks | Sand Barioth Rathalos |
| Evasion Gene (XL) | – | White Shadow | 21 | Evades attacks aimed at the user | – | Up to 2 attacks, 2 turns | Silverwind Nargacuga |
| Bellow Gene (S) | – | War Roar | 19 | Slightly increases all-elemental attack for all allies x1.15 (3 turns) | – | Up to 5 turns | Great Jaggi |
| Bellow Gene (M) | – | Onslaught Roar | 20 | Moderately increases all-elemental attack for all allies x1.2 (3 turns) | – | Up to 5 turns | Monoblos |
| Bellow Gene (L) | – | Merciless Roar | 21 | Greatly increases all-elemental attack for all allies x1.3 (3 turns) | – | Up to 5 turns | Seregios Palamute |
| Charge Gene (M) | – | Focus Power | 10 | Massively increases user’s all-elemental attack next turn | – | Effect+++ 2.2x at max | Bulldrome Diablos Black Diablos |
| Charge Gene (XL) | – | Amplify Power | 10 | Greatly increases user’s all-elemental attack (2 turns) | – | Effect+++ 1.8x at max | Rajang |
| Overpower Gene (S) | – | Overpower | 19 | 80% chance to lower all-elemental attack of all enemies x0.85 (3 turns) | – | Rate++ 100% at max | Velocidrome |
| Overpower Gene (L) | – | Royal Decree | 21 | 80% chance to lower all-elemental attack of all enemies x0.7 (3 turns) | – | Rate++ 100% at max | Ivory Lagiacrus |
| Overpower Gene (XL) | – | Elder Dominance | 40 | 80% chance to lower all-elemental attack of all enemies x0.7 80% chance to lower all-elemental defense of all enemies x0.85 (3 turns) | – | Rate++ 100% at max | Kushala |
| Blinding Gene (S) | – | Flash | 4 | 30% chance to Blind all enemies (3 turns) | – | Rate++ 50% at max | Gypceros Purple Gypceros |
| Cyclone Gene (L) | Technical | Trap Cyclone | 30 | Medium non-elemental damage to all Cyclone targets for continuous damage | No | Power++ | Kushala Sand Barioth |
| One-Shot Attack Gene (M) | Power | Deadly Horn Jab | 28 | Light non-elemental damage to one 10% chance of OHKO | Yes | KO Rate++ 30% at max | White Monoblos |
| P Salt in the Wound Gene | Power | Status Chaser P | 10 | Medium non-elemental damage to one More damage to Status-afflicted enemies | Yes | Power++ | Gypceros |
| S Salt in the Wound Gene | Speed | Status Chaser S | 10 | Medium non-elemental damage to one More damage to Status-afflicted enemies | Yes | Power++ | Cephadrome Palamute |
| T Salt in the Wound Gene | Technical | Status Chaser T | 10 | Medium non-elemental damage to one More damage to Status-afflicted enemies | Yes | Power++ | Yian Garuga |
| Fume Gene (S) | Technical | Poison Gas | 21 | Light non-elemental damage to all 60% chance of Poison (3 turns) | No | Power++ Rate++ 80% at max | Basarios |
| Fume Gene (L) | Technical | Noxious Poison Gas | 28 | Medium non-elemental damage to all 60% chance of Noxious Poison (3 turns) | No | Power++ Rate++ 80% at max | Ruby Basarios |
| Iron Skin Gene (M) | – | Protective Mask | 2 | Immunity to status effects (3 turns) | – | Up to 5 turns | Ash Kecha Wacha |
| Sand Barioth Gene (L) | Speed | Cyclone Chaser | 10 | Medium non-elemental damage to one More damage to enemies in cyclone | Yes | Power++ | Sand Barioth |
| Nargacuga Gene (M) | Speed | Killer Tail | 20 | Medium non-elemental damage to one +20% chance of crit | Yes | Power++ | Nargacuga |
| Gravios Gene (M) | Power | Killer Tackle | 20 | Medium non-elemental damage to one +20% chance of crit | Yes | Power++ | Gravios |
| Nerscylla Gene (M) | Technical | Sleep Chaser | 10 | Medium non-elemental damage to one More damage to Sleeping enemies | Yes | Power++ | Great Baggi Nerscylla |
| Thousand Blades Gene (M) | Technical | Thousand Blades | 24 | Heavy non-elem to one enemy 60% chance of Bleeding (2 turns) | Yes | Power++ Rate++ 80% at max | Seregios Palamute |
| Bubble Flurry Gene (L) | – | Bubbly Dance | 21 | Evade one attack (turn it’s used) | – | Heals on turn used One evade active 2 turns | Mizutsune |
| Nergigante Gene (L) | Speed | Ruinous Strike | 20 | Medium non-elemental damage to one +20% chance of crit | Yes | Power++ Crit Rate++ +30% at max | Nergigante |
| Nergigante Gene (XL) | Power | Calamity Slash | 50 | Massive non-elemental damage to all Lowers user’s defense x0.7, auto-recovers HP (3 turns) | Yes | Power++ | Nergigante |
| Empowering Song Gene (M) | – | Song of Power | 20 | Slightly increases all-elemental attack for all allies x1.2 (3 turns) | – | Up to 5 turns | Qurupeco |
| Fortifying Song Gene (M) | – | Song of Protection | 20 | Slightly increases all-elemental defense for all allies x1.2 (3 turns) | – | Up to 5 turns | Qurupeco |
| Weakening Song Gene (M) | – | Fatigue Song | 16 | 80% chance to slightly lower all-elemental attack for all enemies x0.8 (3 turns) | – | Up to 5 turns | Crimson Qurupeco |
| Enfeebling Song Gene (M) | – | Ruin Song | 16 | 80% chance to slightly lower all-elemental defense for all enemies x0.8 (3 turns) | – | Up to 5 turns | Crimson Qurupeco |