Moon Knight has had several partners within the pages of Marvel Comics, while married to Layla El-Faouly (the Scarlett Scarab) in the Marvel Cinematic Universe. Marc Spector's main love interest throughout "Moon Knight" comics was archaeologist Marlene Alraune. Moon Knight and Marlene have been consistent parts of each other's life, but his violent lifestyle eventually became too much for her. As a result, she moved away from him along with their child, Diatrice. Moon Knight has had several brief romances after Marlene, including one with Tigra after both heroes were part of the West Coast Avengers. Still, he hasn't prioritized his relationships for some time.

Tigra's most prominent relationship in the comics, with Hank Pym, ended up being a nightmare for her. While she initially believed she was pregnant with Pym's child, it was revealed Pym wasn't actually the person she was with, but actually the Skrull Criti Noll during the "Secret Invasion" storyline that's soon coming to the MCU. Due to the circumstances, Tigra has lied to her child William about his father (for a good reason), choosing to tell him the real Pym is his dad and was a great hero.

If Marvel decides Moon Knight and Layla El-Faouly's complicated romance isn't worth continuing, the "Moon Knight" comic book just set up a new (yet old) romance for Marc Spector that would be great to see on the big or small screen. Following a mission to track down a villain who made his surprise return, and Moon Knight lying about his involvement in the situation, Tigra's vulnerability with him just made him realize more than ever how important she is to him.