Given that Los Angeles is in the show's title, the Southern California setting is, also, unlikely to change, and the thrust of the show's action will continue to be focused on the team that viewers have already come to know and love. However, because the show's current season has yet to finish airing, there's a lot that's still up in the air heading into season 13. The show's main characters could be in a very different place when season 12 is over. That said, NCIS: Los Angeles has never been the kind of show that totally abandons its premise.
Even if things change over the remainder of season 12, season 13 will still have some of the usual, familiar elements that give the show it's identity, including undercover missions, witty banter, and in-depth looks at the show's major characters. The specifics may vary, but no matter what, if the show is renewed for another season, special agents Callen and Hanna are likely to continue bringing criminals to justice.
