Home news Pediatric middle ear infections and gastroesophageal reflux - ePrints By Michael Green | Published April 05, 2026 Pediatric middle ear infections and gastroesophageal refluxLookup NU author(s): Dr Petros Karkos,Wolfgang IssingDownloadsFull text for this publication is not currently held within this repository. Alternative links are provided below where available.AbstractObjectives : The pathogenesis of middle ear infections in children is multifactorial and includes infection, anatomical factors, impaired immunologic status, allergy, familial predisposition, mate sex, method of feeding and environmental factors. Glue ear remains the commonest cause of deafness in childhood. Gastroesophageal reflux (GOR) is a common problem in the newborn and preschool periods. Recent research suggests that it may be related to eustachian tube dysfunction and otitis media. Methods : We review the literature and discuss the possible relationship between Gastroesophageal reflux and otitis media in children. Conclusions : The current data are not enough to support antireflux treatment in children with refractory middle ear infections. More prospective randomised placebo-controlled studies are needed. (C) 2004 Elsevier Ireland Ltd. All rights reserved.Publication metadataAuthor(s): Karkos PD, Assimakopoulos D, Issing WJPublication type: ReviewPublication status: PublishedJournal: International Journal of Pediatric OtorhinolaryngologyYear: 2004Volume: 68Issue: 12Pages: 1489-1492ISSN (print): 0165-5876ISSN (electronic): 1872-8464URL: DOI: 10.1016/j.ijporl.2004.07.019Share