On the Gotian's Games YouTube page, the gamer and content creator uploaded a video from "The Last of Us Part II" that sees Ellie (Ashley Johnson) exploring the Seattle Convention Center. However, it's what Ellie finds on the body of one of the many hapless victims of the apocalypse that has raised some eyebrows across the "Supernatural" fandom. The letter states that the writer was on his way to relieve someone named Misha of their duties and is signed by a person called Jensen. Since Jensen Ackles and Misha Collins were major stars of "Supernatural" over its 15-year run, it seems like it would be too much of a coincidence if this wasn't a deliberate reference to the long-running CW series.
When you consider that the bumbling odd couple of Dean and Castiel, who the actors portrayed on the show, were a fan-favorite duo, it becomes even more likely that the letter was made specifically with "Supernatural" fans in mind. While some speculated that the inclusion means that the real-life actors may have perished at a fan convention in this world (via Games Radar), the specifics of the letter cast doubt on that theory.
Details in the letter, for instance, include the SCARS, a survivor group that only emerged many years after the apocalyptic events from the opening of "The Last of Us." Either way, it's probably cooler still to imagine the actors battling monsters in their real lives, even if at least one of them wasn't lucky enough to survive to old age.