Being close to a superhero has its perks — it can definitely add a few colorful wrinkles to date night — but it also inevitably leads to pain. After all, if you have an enemy who has dedicated their entire life to seeing you suffer (as most comics heroes do), a non-superpowered loved one is a flashing neon target.
All of which is to say that with Flash's nemesis Reverse-Flash looking to harm Barry Allen in every possible timeline, Iris may as well have been the base of a house of cards. It was only a matter of time before the supervillain knocked her down to leave Barry in shambles. The bright yellow mastermind isn't one for subtlety, but he was able to find a way to corner Iris without sacrificing any of his characteristic flair. He found Barry's then-wife at a costume party, where he was cleverly disguised as himself. Iris, meanwhile, was dressed as Batgirl, a character with her own history of being attacked by supervillains hoping to extract misery from their nemesis.
The character sometimes known as Zoom used his speed powers to vibrate his hand through her skull. He phased his hand through her head only to slow down with his hand inside, scrambling her brain and killing her instantly.
Though Iris remained dead for a while in Barry's timeline (to his knowledge), she was actually doing well elsewhere. In the meantime, Barry fell in love again — and Zoom, true to form, also attempted to kill his next fiancée.