Some fans have interpreted Enid boarding the out-of-service bus as a metaphor for suicide, though Clowes was initially taken aback by that understanding. In a 2002 interview at a Comics and Graphic Novels Conference (via Little White Lies), he said, "The first time I heard that I said, 'What? You're out of your mind. What are you talking about?' But I've heard that hundreds of times."
Interestingly, the original ending of "Ghost World" saw Seymour dying by suicide. In that same interview, Zwigoff said that he "briefly" considered going that route, "but we toned it down a bit" as it was too dark. Instead, the film ends with Seymour still in therapy and living with his overbearing mother.
Given the actual ending, there's a chance he considered or attempted suicide and moved back home during the recovery stage. He tells his therapist that he's "ready to get back to (his) old life," showing that things might have turned around for him. Given everything Seymour went through, however, it's also possible that he just needed time to recover from his hospitalization and couldn't live alone. Unlike the original ending, it's open for interpretation.
