Regina Crisci hopped into the tank during Episode 14 of Season 13 in 2022.  In the episode, Crisci explains what inspired her to create the product. Showing the Sharks mock dirty diapers, she says that one simply has to sprinkle Diaper Dust onto the used pad, roll it up, and toss it out. The Sharks are duly amazed that the product works so well. Diaper Dust has a patent pending despite some competing products already existing, and she says that the company had only made $3,000 in sales as of the time of the show's taping — all of them via her social media presence and word of mouth. 

Crisci tells the Sharks that as a traveling nurse, she's out of her element in the business arena and has come to the show looking for mentorship. She's offering a 40% equity in the business in exchange for a $75,000 investment, assistance, and advice in finding a professional manufacturing and distribution system.

Crisci's inexperience and the company's steep asking price force most of the Sharks to bow out immediately. Kevin O'Leary, Barbara Corcoran, and Lori Greiner all exit, with O'Leary declaring his diaper-related days are behind him, Corcoran worrying that Crisci is simply a hobbyist with a side hustle, and Grenier thinking it's too soon to join up with the company. Guest Shark Emma Grede is also out, though she encourages Crisci to network with "momfluencers" as she has before.

With only Mark Cuban still in the tank, Crisci becomes visibly emotional, declaring she will do anything from selling her house to quitting nursing to make the company a success. But Cuban can already see how committed she is to the project. He agrees to her proposed deal, and Crisci accepts.