Growing up alongside Hashirama Senju, who many consider the most powerful Hokage, Tobirama should have been set up for success as the Hokage, continuing what his brother started for the Hidden Leaf Village. So, where did it go wrong? 

"The Life of Tobirama Senju" gives a masterful rundown of the Second Hokage's life, showcasing how Tobirama and Hashirama focused on creating a new life for the shinobi world after growing up in a war-ridden world. Because of the ongoing feud between the Senju and Uchiha clans, Tobirama killed Madara's brother Izuna, solidifying Madara's hatred towards the Senju and the shinobi world. Throughout his life, Hashirama urges his brother to accept peace between their people and the Uchiha, but when Tobirama became Hokage, he further marginalized them. 

Tobirama's disdain for the Uchiha began when he was just a boy, as his father used him as a pawn in the two clans' war. The belief that "all Uchiha are bad" was ingrained into Tobirama from the start, so it's no surprise that he always saw them as a threat to Konohagakure's future. When Orochimaru reincarnates the Hokages during the Fourth Great Shinobi War, he informs Tobirama about the legacy he left behind, including how his mistreatment of the Uchiha and his development of Forbidden Jutsus brought them to where they are now.