In an interview with Assignment X, Annie Potts was asked what it was like to be back on a sitcom again with "Young Sheldon," albeit a single-camera sitcom this time around. Potts — who had never seen "The Big Bang Theory" until she was cast in "Young Sheldon" — explained in detail why she prefers the single-camera format. "I started in theatre and I feel very at home doing that," Potts said. "The half-hour live audience shows are such a hybrid. It's like, 'Okay, do I play this for the camera, or do I play this for the audience?' ... I have to say that I prefer to work in a single-camera thing, although sometimes it's a little more difficult to find your rhythm, just because the [multi-camera live] audience will help you along with it if you're missing something. But again, we have these guys [co-creators Chuck Lorre and Steven Molaro], and they both have an absolutely infallible, golden ear, so you can never really go wrong. If you go wrong, they're going to hear it, and they're going to correct it."

Potts echoed this sentiment in an interview with Gold Derby where she continued to talk about how much she enjoyed shooting single-camera, and how much of a challenge it's been for the cast and crew to work in a format that Lorre had never done before. She also mentioned in that interview that Molaro focuses more on creating "moments" rather than jokes, which is different from how multi-camera sitcoms such as "The Big Bang Theory" typically operate. It ultimately makes for a more heartfelt show, Potts noted, and audiences seem to agree.