In a September 2020 interview with Deadline, Millie Bobby Brown opened up about connecting with her title character in "Enola Holmes" — to the point of recognizing herself in the character's actions and traits.

After being asked if she connected to Enola's headstrong nature, Brown revealed that the immediate response of her friends and family has been that they recognize Brown in the character. Brown explained, "They say, 'Oh my gosh, she's so much like you. Sometimes I'm looking at her and I feel like I'm watching you talking.'" And Brown completely agrees. She continued, "So, first of all, that is one of the things that I loved about Enola, is when I was reading the script, it felt like I was reading myself. She's got a very witty sense of humor, very British. And I've definitely got her sense of humor."

Brown also mentioned Enola's bravery and heart as two qualities that she also sees in herself, noting that in her own life she likes to take risks as well as revel in her emotions. Brown told Deadline, "I felt like it's a coming of age story, she's growing up in a crazy world around her, and I'm growing up in a crazy world around me, and it's about how we're finding ourselves."