Skins is a drama about a group of British teens in Bristol, South West England that ran from 2007 to 2013. The show was quite controversial when it aired, as it explores a lot of dark topics—including depression, substance abuse, bipolar disorder, bullying, and death.

A clever teenage girl with a strong grunge style, Scodelario's Skins character Effy is the younger sister of Tony Stonem, played by Nicholas Hoult. Effy is featured in four seasons of the series—the only person to do so—as every two seasons, Skins cycled out new characters and storylines. Effy is the main character in seasons 3 and 4, commonly referred to as the second generation, stirring up trouble in a new group of friends consisting of Freddie (Lucas Pasqualino), Cook (Jack O'Connell), and JJ (Ollie Barbieri). She suffers from depression and bipolar disorder and has difficulty maintaining healthy relationships. 

For seasons 5 and 6 Skins switched the cast, but returned to Effy's story for a two-part episode in the final seventh season. Season 7 also features episodes focused on Cook and Cassie (Hannah Murray), allowing the show to check back in on fan-favorite characters and finish up their storylines. Soon after Skins ended, Scodelario booked The Maze Runner, along with an appearance in the Pirates of the Caribbean film series as Carina Smyth, a clever young astronomer.