There have been talks of making a sequel to The Devil Wears Prada over the years, especially after Weisberger wrote her own sequel to the original novel in 2013 called Revenge Wears Prada: The Devil Returns: That 2013 book, set a decade after the previous one, depicts Andy as the editor of her own magazine, before being drawn into Miranda Priestly's orbit again. Believe it or not, the series even saw a third novel, When Life Gives You Lululemons, published in 2018. However, a film adaptation of the sequel novel — much less the third one — was never made or developed, and a large reason for that has to do with the attitudes of the original Devil Wears Prada cast.

According to Variety, Meryl Streep has privately said that she has no interest in making a Devil Wears Prada sequel. Similarly, Anne Hathaway is quoted saying that, while she'd love to make another film with the Devil Wears Prada cast and crew, she thinks that the original film "might have just hit the right note" and that it's "good to leave it as it is." 

In 2018, via People Magazine, Emily Blunt expressed a similar opinion about a Devil Wears Prada sequel, saying that "if everyone did it I would be up for it," but that she secretly hoped it wouldn't happen because "I think sometimes when you sequel everything kind of dilutes how special the original is."

In other words, while nothing is impossible, it seems that fans of The Devil Wears Prada probably shouldn't start holding their breath for a sequel anytime soon, if ever.